The CSI team works backwards from the gruesome discovery of a human eyeball to discover that a missing woman has been murdered, and both her husband and teenage daughter have shocking motives to want her dead.
Grissom and Nick investigate the murder of Alex James, a man who led police on a high-speed chase before exiting his vehicle and dropping dead with a wooden stake in his head.
Grissom and Catherine investigate the death of a horse trainer who appears to have been trampled to death on a private jet at 30,000 feet by her $1 million race horse.
A deadly bomb explosion at a Vegas office building sends Grissom and the CSI team in search of a serial bomber. Their primary suspect is the building's overly helpful security guard, who knows more than he should about blowing things up.
Grissom and Catherine investigate when a leg is found severed from a body in a lake. Meanwhile, Sara and Nick investigate a fraternity pledging gone terribly wrong.
Grissom and Brass track down a serial killer who stages his murders so that they appear to be suicides. Meanwhile, Willows and Brown investigate a robbery and a homicide.
Catherine violates department protocol when she takes the case of a rape accusation against her ex-husband. Meanwhile, Warrick and Sara search for the missing bullet that will either exonerate or indict a cop for murder.
A couple leaving a restaurant on their anniversary are killed in the street, and their car is stolen. The crime scene is compromised when it rains shortly after the CSIs arrive.
The son of an entrepreneur who helped build Las Vegas is found dead of an apparent drug overdose, but the clues at the crime scene lead the CSI team to suspect that his death has been staged, and that they are looking for a murderer - or two.
Grissom, Nick and Warrick take the case of a jogger who was killed by a wild animal in the park. It gets complicated when they discover that the jogger had his liver removed after he was killed.
On the day Grissom has to evaluate his team, a head is found in the trunk of a car. While Gil and Catherine work on the head, Sara and Nick investigate a body in the desert that's missing its head.
A battered body tells the CSI team a troubling story, and in the course of their investigation, the evidence not only leads them to those responsible for the young man's death, but also reveals surprising information about Grissom's personal life.
Grissom and his crew handle their highest profile case to date when the city's former chief of detectives is slain execution-style in his house following a wild party.