Billy sets off on his motor-trike to fulfil a lifelong dream of travelling along the world's most famous highway. Beginning in Chicago, he goes to the top of the Willis Tower, America's tallest building, before visiting the home of Abraham Lincoln in Illinois and meeting the state's champion pie-maker. Going off-route, Billy heads to Amish country, where he takes a horse-drawn buggy ride, and then talks to two women in St Louis whose homes were recently destroyed by a tornado.
Comedian and motorbike enthusiast Billy Connolly drives the iconic Route 66 in the USA.